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Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response

The highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in nature and threaten public health. Although several viral determinants and host factors that influence the virulence of HPAI H5N1 viruses in mammals have been identified, the detailed molecular mechanism remains poorl...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Zhao, Dongming, Liang, Libin, Wang, Shuai, Nakao, Tomomi, Li, Yanbing, Liu, Liling, Guan, Yuntao, Fukuyama, Satoshi, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355609/
https://ncbi.nlm.nih.gov/pubmed/28100622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02215-16
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