Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response

The highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in nature and threaten public health. Although several viral determinants and host factors that influence the virulence of HPAI H5N1 viruses in mammals have been identified, the detailed molecular mechanism remains poorl...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhao, Dongming, Liang, Libin, Wang, Shuai, Nakao, Tomomi, Li, Yanbing, Liu, Liling, Guan, Yuntao, Fukuyama, Satoshi, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355609/
https://ncbi.nlm.nih.gov/pubmed/28100622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02215-16
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