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Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations
Human mitochondrial DNA (mtDNA) polymerase γ (Pol γ) is the only polymerase known to replicate the mitochondrial genome. The Pol γ holoenzyme consists of the p140 catalytic subunit (POLG) and the p55 homodimeric accessory subunit (POLG2), which enhances binding of Pol γ to DNA and promotes processiv...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5354484/ https://ncbi.nlm.nih.gov/pubmed/28154168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773341 |
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