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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled
Growth hormone regulates its biological properties via a sequential hormone-induced receptor homodimerization mechanism. Using a mutagenesis-scanning analysis of 81 single and 32 pairwise double mutations, we show that the hormone's two spatially distal receptor binding sites (Site1 and Site2)...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC535364/ https://ncbi.nlm.nih.gov/pubmed/15563602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403336101 |
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