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Site2 binding energetics of the regulatory step of growth hormone–induced receptor homodimerization

Receptor signaling in the growth hormone (GH)–growth hormone receptor (GHR) system is controlled through a sequential two-step hormone-induced dimerization of two copies of the extracellular domain (ECD) of the receptor. The regulatory step of this process is the binding of the second ECD (ECD2) to...

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Bibliografiske detaljer
Main Authors: Walsh, Scott T.R., Jevitts, Liz M., Sylvester, Juliesta E., Kossiakoff, Anthony A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323993/
https://ncbi.nlm.nih.gov/pubmed/12930995
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