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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization

Signaling in the human growth hormone (hGH)–human GH receptor system is initiated by a controlled sequential two-step hormone-induced dimerization of two hGH receptors via their extracellular domains (ECDs). Little is currently known about the energetics governing the important regulatory step in re...

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Autors principals: Bernat, Bryan, Pal, Gabor, Sun, Miao, Kossiakoff, Anthony A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC298707/
https://ncbi.nlm.nih.gov/pubmed/12552121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235023100
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