Energetic localization of saxitoxin in its channel binding site.

Saxitoxin (STX) selectively blocks the voltage-gated sodium channel at the outer vestibule lined by P-loops of the four domains. Neosaxitoxin has an additional -OH group at the N1 position of the 1,2,3 guanidinium (N1-OH) that interacts with domains I and IV of the Na(+) channel. Determination of a...

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Hauptverfasser: Choudhary, Gaurav, Shang, Lisa, Li, Xiufeng, Dudley, Samuel C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302195/
https://ncbi.nlm.nih.gov/pubmed/12124273
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