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Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
Kainate receptors are allosterically regulated by sodium ions. Removal of Na(+) from the extracellular solution, or replacement of Na(+) by larger monovalent cations, inhibits kainate receptor activity. Sodium binds at a negatively charged cavity in the extracellular neurotransmitter binding domain...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629458/ https://ncbi.nlm.nih.gov/pubmed/18687343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.07.013 |
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