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Hormone Binding and Co-regulator Binding to the Glucocorticoid Receptor are Allosterically Coupled

The glucocorticoid receptor initiates the cellular response to glucocorticoid steroid hormones in vertebrates. Co-regulator proteins dock to the receptor in response to hormone binding and potentiate the transcriptional activity of the receptor by modifying DNA and recruiting essential transcription...

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Detalhes bibliográficos
Main Authors: Pfaff, Samuel J., Fletterick, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865338/
https://ncbi.nlm.nih.gov/pubmed/20335180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108118
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