A surface on the androgen receptor that allosterically regulates coactivator binding

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might overcome some of these limitations. The...

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Detalhes bibliográficos
Main Authors: Estébanez-Perpiñá, Eva, Arnold, Alexander A., Nguyen, Phuong, Rodrigues, Edson Delgado, Mar, Ellena, Bateman, Raynard, Pallai, Peter, Shokat, Kevan M., Baxter, John D., Guy, R. Kiplin, Webb, Paul, Fletterick, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1999396/
https://ncbi.nlm.nih.gov/pubmed/17911242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708036104
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