A surface on the androgen receptor that allosterically regulates coactivator binding

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might overcome some of these limitations. The...

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Dades bibliogràfiques
Autors principals: Estébanez-Perpiñá, Eva, Arnold, Alexander A., Nguyen, Phuong, Rodrigues, Edson Delgado, Mar, Ellena, Bateman, Raynard, Pallai, Peter, Shokat, Kevan M., Baxter, John D., Guy, R. Kiplin, Webb, Paul, Fletterick, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1999396/
https://ncbi.nlm.nih.gov/pubmed/17911242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708036104
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