A surface on the androgen receptor that allosterically regulates coactivator binding

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might overcome some of these limitations. The...

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Détails bibliographiques
Auteurs principaux: Estébanez-Perpiñá, Eva, Arnold, Alexander A., Nguyen, Phuong, Rodrigues, Edson Delgado, Mar, Ellena, Bateman, Raynard, Pallai, Peter, Shokat, Kevan M., Baxter, John D., Guy, R. Kiplin, Webb, Paul, Fletterick, Robert J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1999396/
https://ncbi.nlm.nih.gov/pubmed/17911242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708036104
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