Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. We previously proposed that compounds recruited to ligand-binding domain (LBD) surfaces could regulate AR activity in hormone-refractory PCa and discovered sev...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Grosdidier, Solène, Carbó, Laia R., Buzón, Víctor, Brooke, Greg, Nguyen, Phuong, Baxter, John D., Bevan, Charlotte, Webb, Paul, Estébanez-Perpiñá, Eva, Fernández-Recio, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416996/
https://ncbi.nlm.nih.gov/pubmed/22653923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1281
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