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The low-affinity binding of second generation radiotracers targeting TSPO is associated with a unique allosteric binding site
[(11)C]-PK11195 (PK11195) has been widely used with positron emission tomography (PET) to assess levels of the translocator protein 18 kDa (TSPO) as a marker of neuroinflammation. Recent ligands, such as [(11)C]-PBR28 and [(11)C]-DPA713, have improved signal-to-noise ratio and specificity for TSPO o...
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| Publicado no: | J Neuroimmune Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5790609/ https://ncbi.nlm.nih.gov/pubmed/28875261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-017-9765-2 |
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