Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo

Neuroblastoma (NB) is one of the most common pediatric malignancies in children. Abnormal activation of receptor tyrosine kinases contributes to the pathological development of NB. Therefore, targeting tyrosine kinase receptors to cure NB is a promising strategy. Here, we report that a multi-targete...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Haoyu, Wang, Yongfeng, Chen, Zhenghu, Lu, Jiaxiong, Pan, Jessie, Yu, Yang, Zhao, Yanling, Zhang, Huiyuan, Hu, Ting, Liu, Qing, Yang, Jianhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351597/
https://ncbi.nlm.nih.gov/pubmed/27564113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11580
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