Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity

Neuroblastoma (NB), the most common extracranial solid tumor of childhood, is responsible for approximately 15% of cancer-related mortality in children. Aberrant activation of cyclin-dependent kinases (CDKs) has been shown to contribute to tumor cell progression in many cancers including NB. Therefo...

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Pubblicato in:Sci Rep
Autori principali: Chen, Zhenghu, Wang, Zhenyu, Pang, Jonathan C., Yu, Yang, Bieerkehazhi, Shayahati, Lu, Jiaxiong, Hu, Ting, Zhao, Yanling, Xu, Xin, Zhang, Hong, Yi, Joanna S., Liu, Shangfeng, Yang, Jianhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932496/
https://ncbi.nlm.nih.gov/pubmed/27378523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29090
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