Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced. These tumors are sensitive to Arg-starvation therapy using pegylated arginine deiminase (ADI-PEG20) which digests extracellula...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Long, Yan, Tsai, Wen-Bin, Chang, Jeffrey T., Estecio, Marcos, Wangpaichitr, Medhi, Savaraj, Naramol, Feun, Lynn G., Chen, Helen H.W., Kuo, Macus Tien
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347722/
https://ncbi.nlm.nih.gov/pubmed/27765932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12308
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