Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence and Glutamine Addiction

Many malignant human tumors, including melanomas are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase1 (ASS1), the rate-limiting enzyme for arginine biosynthesis. Pegylated arginine deiminase (ADI-PEG20), which degrades extracellular arginine resulting in arginine d...

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Hauptverfasser: Long, Yan, Tsai, Wen-Bin, Wangpaichitr, Medhi, Tsukamoto, Takashi, Savaraj, Niramol, Feun, Lynn G., Kuo, Macus Tien
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839414/
https://ncbi.nlm.nih.gov/pubmed/23979920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0302
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