MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

KIT, PDGFRA, NF1 and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterations are required for progression to malignancy. The most frequent secondary alteration, demonstrated in ∼70% of GISTs, is chromosome 1...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Schaefer, Inga-Marie, Wang, Yuexiang, Liang, Cher-wei, Bahri, Nacef, Quattrone, Anna, Doyle, Leona, Mariño-Enríquez, Adrian, Lauria, Alexandra, Zhu, Meijun, Debiec-Rychter, Maria, Grunewald, Susanne, Hechtman, Jaclyn F., Dufresne, Armelle, Antonescu, Cristina R., Beadling, Carol, Sicinska, Ewa T., van de Rijn, Matt, Demetri, George D., Ladanyi, Marc, Corless, Christopher L., Heinrich, Michael C., Raut, Chandrajit P., Bauer, Sebastian, Fletcher, Jonathan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344969/
https://ncbi.nlm.nih.gov/pubmed/28270683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14674
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