MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

KIT, PDGFRA, NF1 and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterations are required for progression to malignancy. The most frequent secondary alteration, demonstrated in ∼70% of GISTs, is chromosome 1...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Schaefer, Inga-Marie, Wang, Yuexiang, Liang, Cher-wei, Bahri, Nacef, Quattrone, Anna, Doyle, Leona, Mariño-Enríquez, Adrian, Lauria, Alexandra, Zhu, Meijun, Debiec-Rychter, Maria, Grunewald, Susanne, Hechtman, Jaclyn F., Dufresne, Armelle, Antonescu, Cristina R., Beadling, Carol, Sicinska, Ewa T., van de Rijn, Matt, Demetri, George D., Ladanyi, Marc, Corless, Christopher L., Heinrich, Michael C., Raut, Chandrajit P., Bauer, Sebastian, Fletcher, Jonathan A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344969/
https://ncbi.nlm.nih.gov/pubmed/28270683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14674
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