Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs

Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood(1-3). A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH)-deficiency and global DNA hyper-methylation(4...

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Publicat a:Nature
Autors principals: Flavahan, William A, Drier, Yotam, Johnstone, Sarah E., Hemming, Matthew L., Tarjan, Daniel R., Hegazi, Esmat, Shareef, Sarah J., Javed, Nauman M., Raut, Chandrajit P., Eschle, Benjamin K., Gokhale, Prafulla C., Hornick, Jason L., Sicinska, Ewa T., Demetri, George D., Bernstein, Bradley E.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913936/
https://ncbi.nlm.nih.gov/pubmed/31666694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1668-3
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