Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome a...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Oncotarget
Main Authors: Kretzschmar, Christin, Roolf, Catrin, Timmer, Katrin, Sekora, Anett, Knübel, Gudrun, Escobar, Hugo Murua, Fuellen, Georg, Ibrahim, Saleh M., Tiedge, Markus, Baltrusch, Simone, Jaster, Robert, Köhling, Rüdiger, Junghanss, Christian
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2016
נושאים:
Research Paper: Gerotarget (Focus on Aging)
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://ncbi.nlm.nih.gov/pubmed/27626489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11952
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