Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells

Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, applications of FLT3 small molecule inhibitors have be...

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Bibliografiske detaljer
Udgivet i:Mol Cell Proteomics
Main Authors: Roolf, Catrin, Dybowski, Nikolaj, Sekora, Anett, Mueller, Stefan, Knuebel, Gudrun, Tebbe, Andreas, Murua Escobar, Hugo, Godl, Klaus, Junghanss, Christian, Schaab, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500767/
https://ncbi.nlm.nih.gov/pubmed/28450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M117.067462
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