Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia

Aberrant PI3K/AKT signaling is a hallmark of acute B-lymphoblastic leukemia (B-ALL) resulting in increased tumor cell proliferation and apoptosis deficiency. While previous AKT inhibitors struggled with selectivity, MK-2206 promises meticulous pan-AKT targeting with proven anti-tumor activity. We he...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Richter, Anna, Fischer, Elisabeth, Holz, Clemens, Schulze, Julia, Lange, Sandra, Sekora, Anett, Knuebel, Gudrun, Henze, Larissa, Roolf, Catrin, Escobar, Hugo Murua, Junghanss, Christian
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967241/
https://ncbi.nlm.nih.gov/pubmed/33803402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052771
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker