Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells

Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, applications of FLT3 small molecule inhibitors have be...

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Detalles Bibliográficos
Publicado en:Mol Cell Proteomics
Main Authors: Roolf, Catrin, Dybowski, Nikolaj, Sekora, Anett, Mueller, Stefan, Knuebel, Gudrun, Tebbe, Andreas, Murua Escobar, Hugo, Godl, Klaus, Junghanss, Christian, Schaab, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500767/
https://ncbi.nlm.nih.gov/pubmed/28450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M117.067462
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