Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome a...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Kretzschmar, Christin, Roolf, Catrin, Timmer, Katrin, Sekora, Anett, Knübel, Gudrun, Escobar, Hugo Murua, Fuellen, Georg, Ibrahim, Saleh M., Tiedge, Markus, Baltrusch, Simone, Jaster, Robert, Köhling, Rüdiger, Junghanss, Christian
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper: Gerotarget (Focus on Aging)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://ncbi.nlm.nih.gov/pubmed/27626489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11952
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