Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kretzschmar, Christin, Roolf, Catrin, Timmer, Katrin, Sekora, Anett, Knübel, Gudrun, Escobar, Hugo Murua, Fuellen, Georg, Ibrahim, Saleh M., Tiedge, Markus, Baltrusch, Simone, Jaster, Robert, Köhling, Rüdiger, Junghanss, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://ncbi.nlm.nih.gov/pubmed/27626489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11952
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