Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging

During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kretzschmar, Christin, Roolf, Catrin, Timmer, Katrin, Sekora, Anett, Knübel, Gudrun, Escobar, Hugo Murua, Fuellen, Georg, Ibrahim, Saleh M., Tiedge, Markus, Baltrusch, Simone, Jaster, Robert, Köhling, Rüdiger, Junghanss, Christian
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper: Gerotarget (Focus on Aging)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342679/
https://ncbi.nlm.nih.gov/pubmed/27626489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11952
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