The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

Ubiquitin-Specific Proteases (USPs) are deubiquitinating enzymes frequently deregulated in human malignancies. Here, we show that USP54 is overexpressed in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes tumorigenesis. We have generated mutant mice...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Español, Yaiza, Freije, José M.P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Priority Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342676/
https://ncbi.nlm.nih.gov/pubmed/27769071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12769
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