Protease Addiction and Synthetic Lethality in Cancer

Por Freije, José M. P., Fraile, Julia M., López-Otín, Carlos
Publicado em 2011

NF-κB in premature aging

Por Osorio, Fernando G., López-Otín, Carlos, Freije, José M. P.
Publicado em 2012

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

Por Osorio, Fernando G., Freije, José M. P., López-Otín, Carlos
Publicado no Cell Cycle (2016)

Deubiquitination in cancer stem cells

Por Fraile, Julia M., Campos-Iglesias, Diana, Freije, José M. P.
Publicado no Aging (Albany NY) (2017)

ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism

Por Cal, Santiago, Freije, José M.P., López, José M., Takada, Yoshikazu, López-Otín, Carlos
Publicado em 2000

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

Por Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Español, Yaiza, Freije, José M.P.
Publicado no Oncotarget (2016)

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

Por Cadiñanos, Juan, Schmidt, Walter K, Fueyo, Antonio, Varela, Ignacio, López-Otín, Carlos, Freije, José M P
Publicado em 2003

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Por Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Publicado em 2010

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Por Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Publicado em 2012

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas

Por Fraile, Julia M., Ordóñez, Gonzalo R., Quirós, Pedro M., Astudillo, Aurora, Galván, José A., Colomer, Dolors, López-Otín, Carlos, Freije, José M.P., Puente, Xose S.
Publicado em 2013

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer

Por Fraile, Julia M., Manchado, Eusebio, Lujambio, Amaia, Quesada, Víctor, Campos-Iglesias, Diana, Webb, Thomas R., Lowe, Scott W., López-Otín, Carlos, Freije, José M. P.
Publicado no J Biol Chem (2017)

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Por ρlvarez-Díaz, Silvia, Valle, Noelia, García, José Miguel, Peña, Cristina, Freije, José M.P., Quesada, Víctor, Astudillo, Aurora, Bonilla, Félix, López-Otín, Carlos, Muñoz, Alberto
Publicado em 2009

Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses

Por Fanjul-Fernández, Miriam, Folgueras, Alicia R., Fueyo, Antonio, Balbín, Milagros, Suárez, María F., Fernández-García, M. Soledad, Shapiro, Steven D., Freije, José M. P., López-Otín, Carlos
Publicado em 2013

Proteomic Profiling of Adipose Tissue from Zmpste24(−/−) Mice, a Model of Lipodystrophy and Premature Aging, Reveals Major Changes in Mitochondrial Function and Vimentin Processing...

Por Peinado, Juan R., Quirós, Pedro M., Pulido, Marina R., Mariño, Guillermo, Martínez-Chantar, Maria L., Vázquez-Martínez, Rafael, Freije, José M. P., López-Otín, Carlos, Malagón, María M.
Publicado em 2011

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

Por Espada, Jesús, Varela, Ignacio, Flores, Ignacio, Ugalde, Alejandro P., Cadiñanos, Juan, Pendás, Alberto M., Stewart, Colin L., Tryggvason, Karl, Blasco, María A., Freije, José M.P., López-Otín, Carlos
Publicado em 2008

Autophagy is essential for mouse sense of balance

Por Mariño, Guillermo, Fernández, Alvaro F., Cabrera, Sandra, Lundberg, Yunxia W., Cabanillas, Rubén, Rodríguez, Francisco, Salvador-Montoliu, Natalia, Vega, José A., Germanà, Antonino, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Publicado em 2010

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis

Por Cabrera, Sandra, Fernández, Álvaro F., Mariño, Guillermo, Aguirre, Alina, Suárez, María F., Español, Yaiza, Vega, José A., Laurà, Rosaria, Fueyo, Antonio, Fernández-García, M. Soledad, Freije, José M.P., Kroemer, Guido, López-Otín, Carlos
Publicado em 2013

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

Por Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos
Publicado em 2011

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Por de la Rosa, Jorge, Freije, José M. P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos
Publicado em 2013

Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

Por Lee, Su-Jin, Jung, Youn-Sang, Yoon, Min-Ho, Kang, So-mi, Oh, Ah-Young, Lee, Jee-Hyun, Jun, So-Young, Woo, Tae-Gyun, Chun, Ho-Young, Kim, Sang Kyum, Chung, Kyu Jin, Lee, Ho-Young, Lee, Kyeong, Jin, Guanghai, Na, Min-Kyun, Ha, Nam Chul, Bárcena, Clea, Freije, José M.P., López-Otín, Carlos, Song, Gyu Yong, Park, Bum-Joon
Publicado no J Clin Invest (2016)