Protease Addiction and Synthetic Lethality in Cancer

od Freije, José M. P., Fraile, Julia M., López-Otín, Carlos
Izdano 2011

NF-κB in premature aging

od Osorio, Fernando G., López-Otín, Carlos, Freije, José M. P.
Izdano 2012

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

od Osorio, Fernando G., Freije, José M. P., López-Otín, Carlos
izdano v Cell Cycle (2016)

Deubiquitination in cancer stem cells

od Fraile, Julia M., Campos-Iglesias, Diana, Freije, José M. P.
izdano v Aging (Albany NY) (2017)

ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism

od Cal, Santiago, Freije, José M.P., López, José M., Takada, Yoshikazu, López-Otín, Carlos
Izdano 2000

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

od Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Español, Yaiza, Freije, José M.P.
izdano v Oncotarget (2016)

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

od Cadiñanos, Juan, Schmidt, Walter K, Fueyo, Antonio, Varela, Ignacio, López-Otín, Carlos, Freije, José M P
Izdano 2003

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

od Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Izdano 2010

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

od Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Izdano 2012

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas

od Fraile, Julia M., Ordóñez, Gonzalo R., Quirós, Pedro M., Astudillo, Aurora, Galván, José A., Colomer, Dolors, López-Otín, Carlos, Freije, José M.P., Puente, Xose S.
Izdano 2013

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer

od Fraile, Julia M., Manchado, Eusebio, Lujambio, Amaia, Quesada, Víctor, Campos-Iglesias, Diana, Webb, Thomas R., Lowe, Scott W., López-Otín, Carlos, Freije, José M. P.
izdano v J Biol Chem (2017)

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

od ρlvarez-Díaz, Silvia, Valle, Noelia, García, José Miguel, Peña, Cristina, Freije, José M.P., Quesada, Víctor, Astudillo, Aurora, Bonilla, Félix, López-Otín, Carlos, Muñoz, Alberto
Izdano 2009

Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses

od Fanjul-Fernández, Miriam, Folgueras, Alicia R., Fueyo, Antonio, Balbín, Milagros, Suárez, María F., Fernández-García, M. Soledad, Shapiro, Steven D., Freije, José M. P., López-Otín, Carlos
Izdano 2013

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.

od Fanjul-Fernández, Miriam, Folgueras, Alicia R., Fueyo, Antonio, Balbín, Milagros, Suárez, María F., Fernández-García, M. Soledad, Shapiro, Steven D., Freije, José M. P., López-Otín, Carlos
izdano v J Biol Chem (2018)

Proteomic Profiling of Adipose Tissue from Zmpste24(−/−) Mice, a Model of Lipodystrophy and Premature Aging, Reveals Major Changes in Mitochondrial Function and Vimentin Processing...

od Peinado, Juan R., Quirós, Pedro M., Pulido, Marina R., Mariño, Guillermo, Martínez-Chantar, Maria L., Vázquez-Martínez, Rafael, Freije, José M. P., López-Otín, Carlos, Malagón, María M.
Izdano 2011

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

od Espada, Jesús, Varela, Ignacio, Flores, Ignacio, Ugalde, Alejandro P., Cadiñanos, Juan, Pendás, Alberto M., Stewart, Colin L., Tryggvason, Karl, Blasco, María A., Freije, José M.P., López-Otín, Carlos
Izdano 2008

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

od Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos
izdano v Nat Med (2019)

Autophagy is essential for mouse sense of balance

od Mariño, Guillermo, Fernández, Alvaro F., Cabrera, Sandra, Lundberg, Yunxia W., Cabanillas, Rubén, Rodríguez, Francisco, Salvador-Montoliu, Natalia, Vega, José A., Germanà, Antonino, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Izdano 2010

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

od Bárcena, Clea, Quirós, Pedro M., Durand, Sylvère, Mayoral, Pablo, Rodríguez, Francisco, Caravia, Xurde M., Mariño, Guillermo, Garabaya, Cecilia, Fernández-García, María Teresa, Kroemer, Guido, Freije, José M.P., López-Otín, Carlos
izdano v Cell Rep (2018)

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis

od Cabrera, Sandra, Fernández, Álvaro F., Mariño, Guillermo, Aguirre, Alina, Suárez, María F., Español, Yaiza, Vega, José A., Laurà, Rosaria, Fueyo, Antonio, Fernández-García, M. Soledad, Freije, José M.P., Kroemer, Guido, López-Otín, Carlos
Izdano 2013