Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic mechanisms. However, the precise nature of the molecular cues involved in this process remains incompletely defined. Here we report that the...

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Detalhes bibliográficos
Main Authors: Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475803/
https://ncbi.nlm.nih.gov/pubmed/23019125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.197954.112
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