Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses

Human MMP-1 is a matrix metalloproteinase repeatedly associated with many pathological conditions, including cancer. Thus, MMP1 overexpression is a poor prognosis marker in a variety of advanced cancers, including colorectal, breast, and lung carcinomas. Moreover, MMP-1 plays a key role in the metas...

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Detalhes bibliográficos
Main Authors: Fanjul-Fernández, Miriam, Folgueras, Alicia R., Fueyo, Antonio, Balbín, Milagros, Suárez, María F., Fernández-García, M. Soledad, Shapiro, Steven D., Freije, José M. P., López-Otín, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656316/
https://ncbi.nlm.nih.gov/pubmed/23548910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439893
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