The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

Colorectal cancer is the third most common cancer worldwide. Although the transcription factor c-MYC is misregulated in the majority of colorectal tumors, it is difficult to target directly. The deubiquitinase USP28 stabilizes oncogenic factors, including c-MYC; however, the contribution of USP28 in...

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Hlavní autoři: Diefenbacher, Markus E., Popov, Nikita, Blake, Sophia M., Schülein-Völk, Christina, Nye, Emma, Spencer-Dene, Bradley, Jaenicke, Laura A., Eilers, Martin, Behrens, Axel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109555/
https://ncbi.nlm.nih.gov/pubmed/24960159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73733
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