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JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, modulates Wnt signalling strength in the intestine. Transgenic gut-specific augmen...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711188/ https://ncbi.nlm.nih.gov/pubmed/19521338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.153 |
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