FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

The Fbxw7 (F-box/WD repeat–containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in several tissues and targets multiple transcriptional activators and protooncogenes for ubiquitin-mediate...

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Main Authors: Babaei-Jadidi, Roya, Li, Ningning, Saadeddin, Anas, Spencer-Dene, Bradley, Jandke, Anett, Muhammad, Belal, Ibrahim, ElSayed E., Muraleedharan, Ranjithmenon, Abuzinadah, Mohammed, Davis, Hayley, Lewis, Annabelle, Watson, Susan, Behrens, Axel, Tomlinson, Ian, Nateri, Abdolrahman Shams
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039859/
https://ncbi.nlm.nih.gov/pubmed/21282377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100830
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