JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, modulates Wnt signalling strength in the intestine. Transgenic gut-specific augmen...

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Main Authors: Sancho, Rocio, Nateri, Abdolrahman S, de Vinuesa, Amaya Garcia, Aguilera, Cristina, Nye, Emma, Spencer-Dene, Bradley, Behrens, Axel
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711188/
https://ncbi.nlm.nih.gov/pubmed/19521338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.153
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