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The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the presence of FBW7 mRNA. To understand the molecular mechanism of FBW7 regulatio...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873885/ https://ncbi.nlm.nih.gov/pubmed/29346117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97325 |
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