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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in cancer. Here, using an shRNA library screen, we ide...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8024278/ https://ncbi.nlm.nih.gov/pubmed/33824312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22319-5 |
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