Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in cancer. Here, using an shRNA library screen, we ide...

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Vydáno v:Nat Commun
Hlavní autoři: Khan, Omar M., Almagro, Jorge, Nelson, Jessica K., Horswell, Stuart, Encheva, Vesela, Keyan, Kripa S., Clurman, Bruce E., Snijders, Ambrosius P., Behrens, Axel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024278/
https://ncbi.nlm.nih.gov/pubmed/33824312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22319-5
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