Lataa...
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the presence of FBW7 mRNA. To understand the molecular mechanism of FBW7 regulatio...
Tallennettuna:
| Julkaisussa: | J Clin Invest |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Clinical Investigation
2018
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873885/ https://ncbi.nlm.nih.gov/pubmed/29346117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97325 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|