Gli1‐induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1

Aberrant activation of the Hedgehog (Hh) signaling pathway drives the tumorigenesis of multiple cancers. In this study, we screened a panel of deubiquitinases that may regulate the Hh pathway. We find that deubiquitinase USP48 activates Gli‐dependent transcription by stabilizing Gli1 protein. Mechan...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Zhou, Aidong, Lin, Kangyu, Zhang, Sicong, Ma, Li, Xue, Jianfei, Morris, Saint‐Aaron, Aldape, Kenneth D, Huang, Suyun
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538423/
https://ncbi.nlm.nih.gov/pubmed/28623188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643124
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