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Gli1‐induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1
Aberrant activation of the Hedgehog (Hh) signaling pathway drives the tumorigenesis of multiple cancers. In this study, we screened a panel of deubiquitinases that may regulate the Hh pathway. We find that deubiquitinase USP48 activates Gli‐dependent transcription by stabilizing Gli1 protein. Mechan...
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| Publicado en: | EMBO Rep |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538423/ https://ncbi.nlm.nih.gov/pubmed/28623188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643124 |
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