Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degrad...

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Publicado en:PLoS One
Main Authors: Park, Ji Eun, Chun, Se-Eun, Reichel, Derek, Min, Jee Sun, Lee, Su-Chan, Han, Songhee, Ryoo, Gongmi, Oh, Yunseok, Park, Shin-Hyung, Ryu, Heon-Min, Kim, Kyung Bo, Lee, Ho-Young, Bae, Soo Kyung, Bae, Younsoo, Lee, Wooin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://ncbi.nlm.nih.gov/pubmed/28273121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173247
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