Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degrad...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Park, Ji Eun, Chun, Se-Eun, Reichel, Derek, Min, Jee Sun, Lee, Su-Chan, Han, Songhee, Ryoo, Gongmi, Oh, Yunseok, Park, Shin-Hyung, Ryu, Heon-Min, Kim, Kyung Bo, Lee, Ho-Young, Bae, Soo Kyung, Bae, Younsoo, Lee, Wooin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://ncbi.nlm.nih.gov/pubmed/28273121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173247
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