Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degrad...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Park, Ji Eun, Chun, Se-Eun, Reichel, Derek, Min, Jee Sun, Lee, Su-Chan, Han, Songhee, Ryoo, Gongmi, Oh, Yunseok, Park, Shin-Hyung, Ryu, Heon-Min, Kim, Kyung Bo, Lee, Ho-Young, Bae, Soo Kyung, Bae, Younsoo, Lee, Wooin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2017
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://ncbi.nlm.nih.gov/pubmed/28273121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173247
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