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Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degrad...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Park, Ji Eun, Chun, Se-Eun, Reichel, Derek, Min, Jee Sun, Lee, Su-Chan, Han, Songhee, Ryoo, Gongmi, Oh, Yunseok, Park, Shin-Hyung, Ryu, Heon-Min, Kim, Kyung Bo, Lee, Ho-Young, Bae, Soo Kyung, Bae, Younsoo, Lee, Wooin
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://ncbi.nlm.nih.gov/pubmed/28273121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173247
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