Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and Bortezomib

Over the past 15 years, proteasome inhibitors (PIs), namely bortezomib, carfilzomib (Cfz) and ixazomib, have significantly improved the overall survival and quality-of-life for multiple myeloma (MM) patients. However, a significant portion of MM patients do not respond to PI therapies. Drug resistan...

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Foilsithe in:J Med Chem
Main Authors: Lee, Min Jae, Bhattarai, Deepak, Yoo, Jisu, Miller, Zach, Park, Ji Eun, Lee, Sukyeong, Lee, Wooin, Driscoll, James J., Kim, Kyung Bo
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675178/
https://ncbi.nlm.nih.gov/pubmed/30964987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01943
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