The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

BACKGROUND AND PURPOSE: Peptides from venomous animals have long been important for understanding pain mechanisms and for the discovery of pain treatments. Here, we hypothesized that Phα1β, a peptide from the venom of the armed spider Phoneutria nigriventer, produces analgesia by blocking the TRPA1...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Tonello, Raquel, Fusi, Camilla, Materazzi, Serena, Marone, Ilaria M, De Logu, Francesco, Benemei, Silvia, Gonçalves, Muryel C, Coppi, Elisabetta, Castro‐Junior, Celio J, Gomez, Marcus Vinicius, Geppetti, Pierangelo, Ferreira, Juliano, Nassini, Romina
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341489/
https://ncbi.nlm.nih.gov/pubmed/27759880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13652
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