Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

Metabolic reprogramming has been described as a hallmark of transformed cancer cells. In this study, we examined the role of the glutamine (Gln) utilization pathway in acute myeloid leukemia (AML) cell lines and primary AML samples. Our results indicate that a subset of AML cell lines is sensitive t...

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發表在:Oncotarget
Main Authors: Matre, Polina, Velez, Juliana, Jacamo, Rodrigo, Qi, Yuan, Su, Xiaoping, Cai, Tianyu, Chan, Steven M., Lodi, Alessia, Sweeney, Shannon R., Ma, Helen, Davis, Richard Eric, Baran, Natalia, Haferlach, Torsten, Su, Xiaohua, Flores, Elsa Renee, Gonzalez, Doriann, Konoplev, Sergej, Samudio, Ismael, DiNardo, Courtney, Majeti, Ravi, Schimmer, Aaron D., Li, Weiqun, Wang, Taotao, Tiziani, Stefano, Konopleva, Marina
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340236/
https://ncbi.nlm.nih.gov/pubmed/27806325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12944
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