Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow–derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML). Here we demonstrate that the CXCR4 inhibitor AMD3465 antagonized stroma...

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Bibliografiske detaljer
Main Authors: Zeng, Zhihong, Xi Shi, Yue, Samudio, Ismael J., Wang, Rui-Yu, Ling, Xiaoyang, Frolova, Olga, Levis, Mark, Rubin, Joshua B., Negrin, Robert R., Estey, Elihu H., Konoplev, Sergej, Andreeff, Michael, Konopleva, Marina
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699240/
https://ncbi.nlm.nih.gov/pubmed/18955566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-158311
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