Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow–derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML). Here we demonstrate that the CXCR4 inhibitor AMD3465 antagonized stroma...

詳細記述

保存先:
書誌詳細
主要な著者: Zeng, Zhihong, Xi Shi, Yue, Samudio, Ismael J., Wang, Rui-Yu, Ling, Xiaoyang, Frolova, Olga, Levis, Mark, Rubin, Joshua B., Negrin, Robert R., Estey, Elihu H., Konoplev, Sergej, Andreeff, Michael, Konopleva, Marina
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2009
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699240/
https://ncbi.nlm.nih.gov/pubmed/18955566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-158311
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料