Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of AML cells. In this study, we used reverse phase-protein array (RPPA) technology to measure changes in multiple proteins induced by stroma in leukemic cells. We then investi...

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Bibliographic Details
Main Authors:	Zeng, Zhihong, Shi, Yue Xi, Tsao, Twee, Qiu, YiHua, Kornblau, Steven M., Baggerly, Keith A., Liu, Wenbin, Jessen, Katti, Liu, Yi, Kantarjian, Hagop, Rommel, Christian, Fruman, David A., Andreeff, Michael, Konopleva, Marina
Format:	Artigo
Language:	Inglês
Published:	American Society of Hematology 2012
Subjects:	Myeloid Neoplasia
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3460689/ https://ncbi.nlm.nih.gov/pubmed/22826565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-393934
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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

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