Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of AML cells. In this study, we used reverse phase-protein array (RPPA) technology to measure changes in multiple proteins induced by stroma in leukemic cells. We then investi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zeng, Zhihong, Shi, Yue Xi, Tsao, Twee, Qiu, YiHua, Kornblau, Steven M., Baggerly, Keith A., Liu, Wenbin, Jessen, Katti, Liu, Yi, Kantarjian, Hagop, Rommel, Christian, Fruman, David A., Andreeff, Michael, Konopleva, Marina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2012
Pynciau:
Myeloid Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460689/
https://ncbi.nlm.nih.gov/pubmed/22826565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-393934
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