Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

Metabolic reprogramming has been described as a hallmark of transformed cancer cells. In this study, we examined the role of the glutamine (Gln) utilization pathway in acute myeloid leukemia (AML) cell lines and primary AML samples. Our results indicate that a subset of AML cell lines is sensitive t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Matre, Polina, Velez, Juliana, Jacamo, Rodrigo, Qi, Yuan, Su, Xiaoping, Cai, Tianyu, Chan, Steven M., Lodi, Alessia, Sweeney, Shannon R., Ma, Helen, Davis, Richard Eric, Baran, Natalia, Haferlach, Torsten, Su, Xiaohua, Flores, Elsa Renee, Gonzalez, Doriann, Konoplev, Sergej, Samudio, Ismael, DiNardo, Courtney, Majeti, Ravi, Schimmer, Aaron D., Li, Weiqun, Wang, Taotao, Tiziani, Stefano, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340236/
https://ncbi.nlm.nih.gov/pubmed/27806325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12944
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