NAD(P)H Oxidase Nox-4 Mediates 7-Ketocholesterol-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Aortic Smooth Muscle Cells

The mechanisms involved in the cytotoxic action of oxysterols in the pathogenesis of atherosclerosis still remain poorly understood. Among the major oxysterols present in oxidized low-density lipoprotein, we show here that 7-ketocholesterol (7-Kchol) induces oxidative stress and/or apoptotic events...

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Главные авторы: Pedruzzi, Eric, Guichard, Cécile, Ollivier, Véronique, Driss, Fathi, Fay, Michèle, Prunet, Céline, Marie, Jean-Claude, Pouzet, Cécile, Samadi, Mohammad, Elbim, Carole, O'Dowd, Yvonne, Bens, Marcelle, Vandewalle, Alain, Gougerot-Pocidalo, Marie-Anne, Lizard, Gérard, Ogier-Denis, Eric
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2004
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC533993/
https://ncbi.nlm.nih.gov/pubmed/15572675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10703-10717.2004
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