NAD(P)H Oxidase Nox-4 Mediates 7-Ketocholesterol-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Aortic Smooth Muscle Cells

The mechanisms involved in the cytotoxic action of oxysterols in the pathogenesis of atherosclerosis still remain poorly understood. Among the major oxysterols present in oxidized low-density lipoprotein, we show here that 7-ketocholesterol (7-Kchol) induces oxidative stress and/or apoptotic events...

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Detalhes bibliográficos
Main Authors: Pedruzzi, Eric, Guichard, Cécile, Ollivier, Véronique, Driss, Fathi, Fay, Michèle, Prunet, Céline, Marie, Jean-Claude, Pouzet, Cécile, Samadi, Mohammad, Elbim, Carole, O'Dowd, Yvonne, Bens, Marcelle, Vandewalle, Alain, Gougerot-Pocidalo, Marie-Anne, Lizard, Gérard, Ogier-Denis, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC533993/
https://ncbi.nlm.nih.gov/pubmed/15572675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10703-10717.2004
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